3/31/2024 0 Comments Pcad 2006 switch sheet![]() ![]() We show that P-cadherin overexpression, in breast cancer cells with wild-type E-cadherin, promotes cell invasion, motility and migration. To achieve this goal, we set up two breast cancer cell models, where P-cadherin expression was differently modulated and analysed in terms of cell invasion, motility and migration. However, little is known about how this protein dictates the very aggressive behaviour of these tumours. In breast cancer, tumours that overexpress P-cadherin usually present a high histological grade, show decreased cell polarity and are associated with worse patient survival. However, during tumour progression, these molecules are frequently altered. Several studies have shown the role mediated by cadherins in this process, besides their role in the maintenance of cell polarity, differentiation and cell growth. Cell–cell adhesion is an elementary process in normal epithelial cellular architecture. ![]()
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